TABLE 3

Comparing the ACCORD BP trial and SPRINT

	ACCORD BP¹³	SPRINT¹
Trial design	Randomized controlled trial, 2 × 2 factorial design—intensive vs standard antihyperglycemic treatment and intensive vs standard antihypertensive treatment	Randomized controlled trial, intensive vs standard antihypertensive treatment
Number of participants	4,733	9,361
Main inclusion criteria	Type 2 diabetes Systolic pressure 130-180 mm Hg Age 40 and older (upper age limit 79)	Systolic pressure 130-180 mm Hg Age 50 and older
Main exclusion criteria	Serum creatinine > 1.5 mg/dL	Stroke, diabetes mellitus
Follow-up	Mean 4.7 years	Median 3.26 years
Mean age	62.2	67.9
Female	47.7%	35.6%
Black	24.1%	29.9%
Baseline cardiovascular disease	33.7%	20.1%
Mean estimated glomerular filtration rate	91.6 mL/min/1.73 m²	71.7 mL/min/1.73 m²
Mean achieved systolic blood pressure	119.3 vs 133.5 mm Hg	121.5 vs 134.6 mm Hg
Mean achieved diastolic pressure	64.4 vs 70.5 mm Hg	68.7 vs 76.3 mm Hg
Mean number of medications	3.4 vs 2.1	2.8 vs 1.8
Diuretic of choice	Hydrochlorothiazide	Chlorthalidone
Primary outcome definition	Composite of nonfatal myocardial infarction, nonfatal stroke, and cardiovascular mortality	Composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, and cardiovascular mortality
Primary outcome results	1.87 vs 2.09%/year	1.65 vs 2.19%/year^a
Individual outcome results
Myocardial infarction	1.13 vs 1.28%/year	0.65 vs 0.78%/year
Stroke	0.32 vs 0.53%/year^a	0.41 vs 0.47%/year
Cardiovascular mortality	0.52 vs 0.49%/year	0.25 vs 0.43%/year^a
Heart failure	0.73 vs 0.78%/year	0.41 vs 0.67%/year^a
All-cause mortality	1.28 vs 1.19%/year	1.03 vs 1.40%/year^a
Adverse events
Hypotension	0.7 vs 0.04%^a	3.4 vs 2.0%^a
Syncope	0.5 vs 0.21%^a	3.5 vs 2.4%^a
Hypokalemia	2.1 vs 1.1%^a	2.4 vs 1.6%^a

↵a P<.05.
Information from ACCORD Study Group; Cushman WC, Evans GW, Byington RP, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010; 362:1575-1585 and SPRINT Research Group; Wright JT Jr, Williamson JD, Whelton PK, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015; 373:2103-21 16.