Benefit vs harm of intensive and standard systolic pressure control in SPRINT
| Outcome | Absolute risk reduction | Number needed to treat |
|---|---|---|
| Primary outcome | -1.6% | 61 |
| Heart failure | -0.8% | 125 |
| Cardiovascular mortality | -0.6% | 167 |
| All-cause mortality | -1.2% | 83 |
| Absolute risk increase | Number needed to harm | |
| Hypotension | +1.0% | 100 |
| Syncope | +0.6% | 167 |
| Electrolyte abnormalities | +0.8% | 125 |
| Acute kidney injury | +1.6% | 62 |
Information from SPRINT Research Group; Wright JT Jr, Williamson JD, Whelton PK, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015; 373:2103-21 16.