Outcome | Percent per year | Hazard ratio | |
---|---|---|---|
Intensive therapy | Standard therapy | ||
Primary outcomea | 1.65 | 2.19 | 0.75b |
Secomdary outcomes | |||
Myocardial infarction | 0.65 | 0.78 | 0.83 |
Other acute coronary syndromes | 0.27 | 0.27 | 1.00 |
Stroke | 0.41 | 0.47 | 0.89 |
Heart failure | 0.41 | 0.67 | 0.62b |
Cardiovascular mortality | 0.25 | 0.43 | 0.57b |
Other secondary outcomes | |||
All-cause mortality | 1.03 | 1.40 | 0.73b |
In patients with chronic kidney disease—decrease in eGFR of ≥ 50% or end-stage renal disease | 0.33 | 0.36 | 0.89 |
In patients without chronic kidney disease—decrease in eGFR of ≥ 30% to < 60 mL/min/1.73 m2 | 1.21 | 0.35 | 3.49b |
Adverse events | Percent of patients | Hazard ratio | |
---|---|---|---|
Intensive therapy | Standard therapy | ||
Hypotension | 3.4 | 2.0 | 1.70b |
Syncope | 3.5 | 2.4 | 1.44b |
Hyponatremia | 3.8 | 2.1 | 1.76b |
Hypokalemia | 2.4 | 1.6 | 1.50b |
Injurious fall | 7.1 | 7.1 | 1.00 |
Orthostatic hypotension without dizziness | 16.6 | 18.3 | 0.88b |
Orthostatic hypotension with dizziness | 1.3 | 1.5 | 0.85 |
Acute kidney injury | 4.4 | 2.6 | 1.71b |
↵a The composite of myocardial infarction, acute coronary syndrome, stroke, heart failure, or death from cardiovascular causes.
↵b P<.05.
eGFR = estimated glomerular filtration rate, according to the Modification of Diet in Renal Disease study equation.
Information from SPRINT Research Group; Wright JT Jr, Williamson JD, Whelton PK, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015; 373:2103-21 16.