TABLE 2

Mechanism of toxicity of drugs and herbal supplements known to cause acute liver failure

Drug or supplementPattern of injury
TerbinafineCholestatic and mixed
SulfasalazineCholestatic or mixed
Trimethoprim-sulfamethoxazoleCholestatic or mixed
IsoniazidHepatocellular
CarbamazepineHepatocellar, cholestatic, or mixed
Valproic acidHepatocellular
PhenytoinHepatocellular, cholestatic, or mixed
HerbalifeHepatocellular
HydroxycutHepatocellular, cholestatic, or mixed
Kava kavaHepatocellular
OxyElite ProHepatocellular