TABLE 1

Aontiplatelet agents

DrugMetabolic activationReversibilityTime to peak activityElimination half-lifeDuration of effectEliminationDosage
AspirinBy esterases in gastrointestinal mucosaNo1–2 hours3 hours7–10 daysRenal162–325 mg loading dose, then 81–162 mg daily
ClopidogrelBy CYP450No2–6 hours6 hours5–7 daysRenal and gastrointestinal300–600 mg loading dose, then 75 mg daily
PrasugrelBy CYP450No0.5–4 hours2–15 hours5–9 daysRenal and gastrointestinal60 mg loading dose, then 10 mg daily
TicagrelorNoYes0.5–2 hours7–9 hours3–5 daysGastrointestinal and renal180 mg loading dose, then 90 mg twice a day
CangrelorNoYes2–30 minutes3–5 minutes0–30 minutesRenal and gastrointestinal4 μg/kg/min intravenous infusion