Bleeding risk after percutaneous coronary intervention: Triple thrombotic therapy vs dual antiplatelet therapy

AuthorsNo. of patientsAbsolute difference in major bleeding with warfarinComments
Khurram et al,49 20061076.6% higherBleeding defined as requiring > 2 units of packed red blood cells, or intraocular or disabling bleeding
DeEugenio et al,52 200719411% higherHazard ratio 5.0 (95% confidence interval [CI] 1.4–17.8) with warfarin
Karjalainen et al,40 20074785.6% higherOdds ratio 3.4 (95% CI 1.2–9.3) with warfarin
Increased stent thrombosis with warfarin-aspirin combination
Ruiz-Nodar et al,53 20084265.9% higherAll patients had atrial fibrillation
Mortality rate was higher without anticoagulation
Sarafoff et al,54 20085151.7% lower (not statistically significant)Both dual antiplatelet therapy and triple therapy had favorable efficacy and safety
Rossini et al,55 2008b2040.9% higher (not statistically significant)Bleeding rate was lower if the international normalized ratio was kept between 2 and 2.5: 4.9% vs 33% at 3 months
  • a This was a prospective study. The other studies in this table were retrospective.