Key findings of publications from the US Registry for Fibromuscular Dysplasia

Olin et al8 (2012)
  • First publication from the US Registry

  • Extracranial carotid FMD is as common as renal FMD

  • Defined common symptoms, including hypertension, headache, and pulsatile tinnitus

Kim et al10 (2013)
  • Only 8.5% of registrants were male

  • Renal involvement was higher in men than in women (89.7% vs 74.1%); extracranial involvement was more common in women than in men (74.9% vs 44.1%)

  • Compared with women, men were twice as likely to have an aneurysm (40.8% vs. 20.4%) or dissection (39.6% vs 20.0%)

  • Renal artery dissection with flank pain and infarction was a pattern of disease presentation in men with FMD

Weinberg et al11 (2015)
  • High rate of antiplatelet and antihypertensive therapy among registrants

  • 72.9% of FMD patients were on antiplatelet therapy (58.8% on aspirin alone, 4.6% on clopidogrel only)

  • 71.7% of patients were on antihypertensive medications, with 21.5% on three or more

Green et al12 (2016)
  • Mean age at the time of diagnosis in pediatric patients was 8.4 ± 4.8 years

  • Significantly more male patients in the pediatric FMD population vs the adult FMD population (42.2% vs 6.0%)

  • Compared with adults, pediatric patients more likely to have renal artery involvement (97% vs 69.7%) and mesenteric artery involvement (38.9% vs 16.2%)

  • More pediatric FMD patients than adult FMD patients reported having a family member with FMD (17.2% vs 4.7%)

Kadian-Dodov et al7 (2016)
  • 21.7% of patients in the registry had an aneurysm, 25.7% had a dissection, and 41.7% had an aneurysm or dissection

  • Roughly one-third of patients with aneurysm required intervention, most commonly for those found in the extracranial carotid, renal, and intracranial arteries

O’Connor et al3 (2016)
  • 34.5% of patients in the registry were current or former smokers

  • Smoking history was associated with worse outcomes than in nonsmokers, including an increased need for revascularization (45.9% vs 36.7%), and a higher likelihood of aneurysm (24.8% vs 18.9%) and adverse symptoms such as claudication (15.1% vs 7.4%)

  • FMD = fibromuscular dysplasia

  • Data from references 3, 7, 8, 1012.