TABLE 2

Thrombolytic agents

Agent

Loading dose

Maintenance dose

Fibrin specificity

Alteplase^{^a,^b}

10 mg over 10 minutes

90 mg over 2 hours

Moderate

Desmoteplase^c

125–250 μg/kg over 1–2 minutes

None

High

Reteplase^a

10-unit bolus

10-unit bolus given 30 minutes after initial dose

Low

Streptokinase³

250,000 units over 30 minutes

100,000 units/hour over 12–24 hours

None

Tenecteplase^b

Weight-based bolus over 5–10 seconds
< 60 kg	30 mg
60–69	kg 35 mg
70–79	kg 40 mg
80–89	kg 45 mg
≥ 90 kg	50 mg

None

High

Urokinase^a

4,400 units/kg over 10 minutes

4,400 units/kg/hour over 12–24 hours

None

↵a Approved by US Food and Drug Administration for use in acute pulmonary embolism
↵b Available in the United States
↵c In phase 2 trials