Definitions of submassive pulmonary used in various studies
| Study | Definition |
|---|---|
| MAPPET-326 | Acute pulmonary embolism with right ventricular dysfunction/strain or pulmonary hypertension confirmed by echocardiography, electrocardiography, or right-heart catheterization |
| PEITHO29 | Right ventricular dysfunction confirmed by computed tomography (CT) or echocardiography with evidence of myocardial injury confirmed with positive troponin I or T |
| TOPCOAT30 | Pulmonary embolism in patients with combined right ventricular dysfunction on echocardio- graphic examination and elevated biomarkers |
| MOPETT28 | Pulmonary embolism diagnosed on CT pulmonary angiography performed within 24 hours and normal arterial systolic blood pressure with evidence of right ventricular strain, manifested by: Hypokinesis on echocardiography, Elevated troponin I or T, or B-type naturietic peptide (BNP) > 90 pg/mL or NT-pro-BNP > 900 pg/mL |
| Wang et al31 | Signs and symptoms of pulmonary embolism plus CT pulmonary angiographic involvement of > 70% of thrombus in two or more lobar or left or right main pulmonary arteries or by a high probability ventilation-perfusion scan showing ventilation-perfusion mismatch in two or more lobes |
MAPPET 3 = Management Strategies and Prognosis of Pulmonary Embolism-3; MOPETT = Moderate Pulmonary Embolism Treated With Thrombolysis; PEITHO = Pulmonary Embolism Thrombolysis; TOPCOAT = Tenecteplase or Placebo, Cardiopulmonary Outcomes at Three Months