Angiotensin-neprilysin inhibition for managing heart failure

Generic nameDosing range
Sacubitril-valsartan24–26 mg, 49–51 mg, or 97–103 mg twice daily
If tolerated for 2–4 weeks, double the daily dose until target dose of 97–103 mg twice daily is reached
For patients converting from an ACE inhibitor, this medication should be started 36 hours after discontinuation of the ACE inhibitor