Differential diagnosis of thrombotic thrombocytopenic purpura
| Hemolytic-uremic syndrome |
| Atypical hemolytic-uremic syndrome |
| Disseminated intravascular coagulation and sepsis |
| Idiopathic thrombocytopenic purpura |
| Evans syndrome |
| Malignant hypertension |
| Solid organ or bone marrow transplant |
| Severe vasculitis |
| Pregnancy (preeclampsia, eclampsia, HELLP syndrome) |
| Human immunodeficiency virus infection |
| Liver disease |
| Heavy alcohol intake |
| Disseminated malignancy |
| Drugs (eg, clopidogrel, ticlopidine, cyclosporine, mitomycin C, tacrolimus, quinine, gemcitabine) |
| Combined chemotherapy |
| Total body irradiation |
| Malfunctioning prosthetic cardiac valve |
| Cocaine use |
HELLP = hemolysis, elevated liver enzymes, and low platelet count