Treatment recommendations for common sexually transmitted infections
Organism | Treatment | Alternatives |
---|---|---|
Chlamydia trachomatis | Azithromycin 1 g by mouth, 1 dose or Doxycycline 100 mg by mouth twice daily for 7 days | Erythromycin base 500 mg by mouth every 6 hours for 7 days or Erythromycin ethylsuccinate 800 mg by mouth every 6 hours for 7 days or Ofloxacin 300 mg by mouth twice daily for 7 days or Levofloxacin 500 mg by mouth daily for 7 days |
Neisseria gonorrhoeae (uncomplicated infection) | Ceftriaxone 250 mg intramuscularly, 1 dose and Azithromycin 1 g by mouth Gonococcal conjunctivitis: ceftriaxone 1 g intramuscularly, 1 dose | History of severe cephalosporin allergy: Gentamicin 240 mg intramuscularly plus Azithromycin 2 g by mouth, 1 dose |
N gonorrhoeae (disseminated infection) | Ceftriaxone 1 g intravenously or intramuscularly every 24 hours or Cefotaxime 1 g intravenously every 8 hours or Ceftizoxime 1 g intravenously every 8 hours plus concurrent treatment for chlamydia | Can switch to an oral antibiotic based on susceptibilities 24–48 hours after clinical improvement for 7 days of treatment |
Mycoplasma genitalium | Azithromycin 1 g by mouth, 1 dose or Azithromycin 500 mg by mouth, 1 dose and then 250 mg by mouth for 4 more days (limited by resistance) | Moxifloxacin 400 mg by mouth for 7–14 days |
Trichomonas vaginalis | Metronidazole 500 mg by mouth twice a day for 7 days or Metronidazole 2 g by mouth, 1 dose | Tinidazole 2 g by mouth, 1 dose; or 1 g by mouth every day for 5 days |
Adapted from US Centers for Disease Control and Prevention, reference 7