Natural history of peripheral artery disease

Symptoms at diagnosis in patients with PADPatients (%)5-Year outcomes
Asymptomatic20–50Major adverse limb events
Atypical leg discomfort40–50 Stable claudication: 70%–80%
Claudication10–30 Lower extremity revascularization: 10%–20%
 Critical limb ischemia: 1%–2%
Major adverse cardiovascular events
 Myocardial infarction/stroke: 20%
 Death: 15%–30%
1-year outcomes
Critical limb ischemia1–2Amputation: 25%
  • Source: Data from reference 6.