Cutaneous adverse effects of epidermal growth factor receptor inhibitors
| Examples | Cutaneous side effects | Management strategies |
|---|---|---|
| Cetuximab Erlotinib Gefitinib Panitumumab | Papulopustular acneiform eruption | Prevention with minocycline or doxycycline Topical and systemic corticosteroids, antibiotics, oral isotretinoin Oral histamine 1 (H1) antihistamines and gamma aminobutyric acid agonists for pruritus |
| Paronychial inflammation | Topical antibiotics, topical corticosteroids, electrodessication for larger lesions, rarely photodynamic therapy | |
| Stevens-Johnson syndrome–toxic epidermal necrolysis | Discontinue therapy |