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- A 24-year-old man with severe hemolytic anemia and variable Coombs test results
The patient was admitted to the hospital because of dark urine, jaundice, fatigue, and confusion.
- Getting stuck on a name: An example of an eponymous syndrome
Debate continues about whether we should continue to use eponymous diagnostic nomenclature or shift entirely to an anatomic or pathophysiologic descriptive terminology.
- ‘Boxing glove’ hands in a patient initially diagnosed with RS3PE syndrome
The patient had edema that limited finger flexion, impairing daily tasks such as putting on socks.
- Alpha-1 antitrypsin deficiency: A persistently underrecognized condition
Detecting alpha-1 antitrypsin deficiency early is imperative because diagnostic delay is associated with harm, including worsened clinical status and impaired survival.
- Optimizing bowel preparation for colonoscopy: Updated consensus recommendations
Key updates in the 2025 guideline include simplifying dietary restrictions to low-residue foods for a single day before colonoscopy, preferring 2-L over 4-L preparation regimens, and universally recommending split-dose administration.
- Westermark sign (focal oligemia) in pulmonary embolism
The patient’s chest radiograph showed a focal area of reduced blood flow in the middle and upper zones of the right lung.
- Ogilvie syndrome (colonic pseudo-obstruction)
Two days after the patient underwent surgery to repair a left femur fracture, his abdomen became markedly distended, but without pain.
Polycystic ovary syndrome: An update on diagnosis and managementBecause this syndrome affects health throughout the lifespan, long-term management is essential, not only to control symptoms but also to prevent associated metabolic conditions.
- Xanthomas: A clue to undiagnosed lipid disorders
Given the wide availability of direct-to-consumer laboratory testing, it is reasonable to ask whether a working knowledge of xanthomas still matters for trainees and clinicians.
- A new direction in pain management?
It would be nice to have a treatment option for pain that is less limited by side effects, cognitive dysfunction, addiction potential, and red tape.
Cleveland Clinic Journal of Medicine, published by Cleveland Clinic, provides busy clinicians with practical information to promote better patient care.