Regular ArticleDHEA and Its Transformation into Androgens and Estrogens in Peripheral Target Tissues: Intracrinology☆
References (106)
- et al.
The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases
J Steroid Biochem Mol Biol
(1995) - et al.
Expression cloning and characterization of oxidative 17β- and 3α-hydroxysteroid dehydrogenase from rat and human prostate
J Biol Chem
(1997) - et al.
Human 17β-hydroxysteroid dehydrogenase: Overproduction using a baculovirus expression system and characterization
J Steroid Biochem Mol Biol
(1994) - et al.
Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women
Am J Obstet Gynecol
(1993) - et al.
Maximum androgen blockade in advanced prostate cancer: A meta-analysis of published randomized controlled trials using nonsteroidal antiandrogens
Urology
(1997) - et al.
Treatment of hirsutism with the pure antiandrogen flutamide
J Am Acad Dermatol
(1990) - et al.
Comparison of flutamide and spironolactone in the treatment of hirsutism: A randomized controlled trial
Fertil Steril
(1994) - et al.
Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor
J Biol Chem
(1996) - et al.
Expression of human 17β-hydroxysteroid dehydrogenase in mammalian cells
J Steroid Biochem Mol Biol
(1992) - et al.
Characterization, expression and immunohistochemical localization of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in human skin
J Invest Dermatol
(1992)
Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues
J Biol Chem
(1998)
Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20A resolution
Structure
(1995)
Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone
Adv Enzyme Regul
(1987)
Characterization and chromosomal mapping of human steroid 5α-reductase gene and pseudogene and mapping of the mouse homologue
Genomics
(1991)
Clinical, biochemical, radiographic, epidemiologic, and economic features of osteoporosis
Orthop Clin N Am
(1981)
Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes
Genomics
(1997)
Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)
FEBS Lett
(1999)
Intracrinology
Mol Cell Endocrinol
(1991)
Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: A marked improvement in response and survival
J Steroid Biochem
(1985)
The key role of 17β-HSDs in sex steroid biology
Steroids
(1997)
Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues
J Steroid Biochem Mol Biol
(1992)
Structure and tissue-specific expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues
J Steroid Biochem Mol Biol
(1992)
Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in formation of sex steroids in classical and peripheral intracrine tissues
Characterization of human 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene and its expression in mammalian cells
J Biol Chem
(1990)
Subunit identity of the dimeric 17β-hydroxysteroid dehydrogenase from human placenta
J Biol Chem
(1992)
Absorption and metabolic effects of different types of estrogens and progestogens
Obstet Gynecol Clin N Am
(1987)
Characterization, expression and immunohistochemical localization of 5α-reductase in human skin
J Invest Dermatol
(1994)
Characteristics of human types 1, 2, and 3 17β-hydroxysteroid dehydrogenase activities: Oxidation-reduction and inhibition
J Steroid Biochem Mol Biol
(1995)
Obesity in the dog: Role of the adrenal steroid dehydroepiandrosterone (DHEA)
J Nutr
(1991)
Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD), 17β-HSD 5α-reductase and aromatase activities in the rhesus monkey
Mol Cell Endocrinol
(1994)
Comparison of pharmacodynamic properties of various estrogen formulations
Am J Obstet Gynecol
(1982)
3β-Hydroxysteroid dehydrogenase activity in tissues of human fetus determined with 5α-androstane-3β,17β-diol and dehydroepiandrosterone as substrates
J Steroid Biochem Mol Biol
(1993)
Ontogeny and subcellular localization of 3β-hydroxysteroid dehydrogenase (3β-HSD) in the human and rat adrenal, ovary and testis
J Steroid Biochem Mol Biol
(1992)
Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA
FEBS Lett
(1988)
Sebaceous gland response in man to the administration of testosterone, Δ4-androstenedione and dehydroisoandrosterone
J Invest Dermatol
(1969)
Molecular basis of human 3β-hydroxysteroid dehydrogenase deficiency
J Steroid Biochem Mol Biol
(1995)
Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells
Clin Immunol Immunopathol
(1991)
Reduced testosterone and adrenal C19 steroid levels in obese men
Metabolism
(1995)
Molecular cloning of a novel widely expressed human 80 kDa 17β-hydroxysteroid dehydrogenase IV
Biochem J
(1995)
Deletion of steroid 5α-reductase 2 gene in male pseudophermaphroditism
Nature
(1991)
Structural and biochemical properties of cloned and expressed human and rat steroid 5α-reductases
Proc Natl Acad Sci USA
(1990)
Jacques B, Brenner BM. Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease
Mol Cell Biol
(1993)
The distribution of hydroxysteroid dehydrogenase in human sebaceous glands
Br J Dermatol
(1966)
Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer
J Clin Endocrinol Metab
(1986)
Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
J Clin Endocrinol Metab
(1994)
Maximum androgen-blockade with medical or surgical castration in advanced prostate cancer: A meta-analysis of nine published randomized controlled trials and 4128 patients using Flutamide
Prostate Cancer Prostatic Dis
(1999)
Fadrozole HCL (CGS-16949A) versus megestrol acetate treatment of post-menopausal patients with metastatic breast carcinoma: Results of 2 randomized double-blind controlled multiinstitutional trials
Cancer
(1996)
Adrenal steroid precursors exert potent androgenic action in the hamster sebaceous glands of flank organs and ears
Endocrinology
(1996)
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice
Diabetes
(1982)
Effect of dehydroepiandrosterone and the antiestrogen EM-800 on the growth of human ZR-75-1 breast cancer xenografts
J Natl Cancer Inst
(1998)
Cited by (0)
- ☆
Address correspondence and reprint requests to Fernand Labrie, Oncology and Molecular Endocrinology Research Center, Laval University Medical Center (CHUL), 2705 Laurier Boulevard, Quebec City, Quebec, G1V 4G2, Canada. Fax: (418) 654-2735. E-mail: [email protected].
Copyright © 2001 Academic Press. All rights reserved.