Abstract
Antisynthetase syndrome is a heterogeneous idiopathic inflammatory myopathy. Anti-Jo1 is the most common antibody found in this condition. Dermatomyositis is known to be associated with malignancy, but the association between antisynthetase syndrome and malignancy is not clearly established. We report a case of an association of squamous cell carcinoma of the lung and anti-Jo1 antisynthetase syndrome. A 67-year-old man presented with polyarthritis, muscle weakness of the pelvic girdle, “mechanic’s hands,” and weight loss. A diagnosis of antisynthetase syndrome was considered based on the clinical features and the presence of anti-Jo1 antibodies. Positron emission tomography was performed because of weight loss and revealed a pulmonary hypermetabolic lesion. Histological findings revealed squamous cell carcinoma. The patient underwent lobectomy and is currently free of symptoms with regular monitoring. This unusual presentation of squamous cell carcinoma of the lung illustrates the need of a systematic approach to the diagnosis of antisynthetase syndrome. Positron emission tomography can be a useful imaging modality in the diagnosis of paraneoplastic syndromes associated with antisynthetase syndrome especially in the presence of warning signs/symptoms.
Similar content being viewed by others
References
Hervier B, Wallaert B, Hachulla E, Adoue D, Lauque D, Audrain M et al (2010) Clinical manifestations of anti-synthetase syndrome positive for anti-alanyl-tRNA synthetase (anti-PL12) antibodies: a retrospective study of 17 cases. Rheumatology 49:972–976
Marie I, Josse S, Hatron PY, Dominique S, Hachulla E, Janvresse A et al (2013) Interstitial lung disease in anti-Jo-1 patients with antisynthetase syndrome. Arthritis Care Res 65:800–808
Buchbinder R, Hill CL (2002) Malignancy in patients with inflammatory myopathy. Curr Rheumatol Rep 4:415–426
Marie I, Guillevin L, Menard J-F, Hatron PY, Cherin P, Amoura Z et al (2012) Hematological malignancy associated with polymyositis and dermatomyositis. Autoimmun Rev 11:615–620
Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A et al (2001) Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. The Lancet 357:96–100
Imbert-Masseau A, Hamidou M, Agard C, Grolleau JY, Chérin P (2003) Antisynthetase syndrome. Jt Bone Spine 70:161–168
Hervier B, Devilliers H, Stanciu R, Meyer A, Uzunhan Y, Masseau A et al (2012) Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity. Autoimmun Rev 12:210–217
Marie I, Hatron PY, Dominique S, Cherin P, Mouthon L, Menard J-F et al (2012) Short-term and long-term outcome of anti-Jo1-positive patients with anti-Ro52 antibody. Semin Arthritis Rheum 41:890–899
Iwasaki Y, Mohri T, Muraki M, Yasukawa A, Fujimoto T, Takagi O (1992) et al [A case of interstitial pneumonitis associated with polymyositis complicated by renal cell carcinoma]. Nihon Kyōbu Shikkan Gakkai Zasshi 30:1858–1863
Watkins J, Farzaneh-Far R, Tahir H, Wykes F, Studdy PR, Beynon HLC (2004) Jo-1 syndrome with associated poorly differentiated adenocarcinoma. Rheumatol Oxf 43:389–390
van der Bijl AE, Meinders AE, van Duinen SG, Tamsma JT (2005) A nasal squamous cell carcinoma complicated by a paraneoplastic syndrome consisting of a myositis and anti-Jo-1 autoantibodies. Eur J Intern Med 16:369–371
Nakanishi S (2006) Hatayama T [Adenocarcinoma of the prostate associated with anti Jo-1 antibody positive polymyositis]. Hinyokika Kiyo 52:289–291
Respicio G, Shwaiki W, Abeles M (2007) A 58-year-old man with anti-Jo-1 syndrome and renal cell carcinoma: a case report and discussion. Conn Med 71:151–153
Legault D, McDermott J, Crous-Tsanaclis AM, Boire G (2008) Cancer-associated myositis in the presence of anti-Jo1 autoantibodies and the antisynthetase syndrome. J Rheumatol 35:169–171
Rozelle A, Trieu S, Chung L (2008) Malignancy in the setting of the anti-synthetase syndrome. J Clin Rheumatol 14:285–288
Przybylski G, Jarzemska A, Czerniak J, Siemiatkowska K, Gadzińska A, Cieśliński K (2008) A case report of a patient with dermatomyositis as a prodromal sign of lung cancer. Pol Arch Med Wewnętrznej 118:143–147
Mileti LM, Strek ME, Niewold TB, Curran JJ, Sweiss NJ (2009) Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience. J Clin Rheumatol 15:254–255
Castañeda-Pomeda M, Prieto-González S, Grau JM (2011) Antisynthetase syndrome and malignancy: our experience. J Clin Rheumatol 17:458
Vincze M, Molnár PA, Zilahi E, Kapitány A, Dezso B, Takács I et al (2011) Primary lung adenocarcinoma associated with anti-Jo-1 positive polymyositis. Jt Bone Spine 78:209–211
Bragado L, Ruiz Gutiérrez L, Cuende E, López González JL (2013) Kaposi’s sarcoma in a steroid-treated antisynthethase antibody syndrome patient. Reumatol Clin 9:243–245
Courties A, Lidove O, Maisonobe T, Rigolet A, Hermet A, Girard P (2014) et al [Antisynthetase syndrome and lung carcinoma: a fortuitous association?]. Rev Méd Intern 35:271–273
Marie I, Hatron P-Y, Cherin P, Hachulla E, Diot E, Vittecoq O et al (2013) Functional outcome and prognostic factors in anti-Jo1 patients with antisynthetase syndrome. Arthritis Res Ther 15:R149
Trallero-Araguás E, Grau-Junyent JM, Labirua-Iturburu A, García-Hernández FJ, Monteagudo-Jiménez M, Fraile-Rodriguez G et al (2016) Clinical manifestations and long-term outcome of anti-Jo1 antisynthetase patients in a large cohort of Spanish patients from the GEAS-IIM group. Semin Arthritis Rheum 46(2):225–231
Marie I, Josse S, Decaux O, Dominique S, Diot E, Landron C et al (2012) Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 positive patients with antisynthetase syndrome. Autoimmun Rev 11:739–745
Corte RL, naco ALM, Locaputo A, Dolzani F, Trotta F (2006) In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung disease. Autoimmunity 39:249–253
Chinoy H, Adimulam S, Marriage F, New P, Vincze M, Zilahi E et al (2012) Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study. Ann Rheum Dis 71:961–965
Acknowledgements
The authors did not receive any grant or industrial support.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflits of interest
The authors state explicitly that there are no conflicts of interest in connection with this article.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Boleto, G., Perotin, JM., Eschard, JP. et al. Squamous cell carcinoma of the lung associated with anti-Jo1 antisynthetase syndrome: a case report and review of the literature. Rheumatol Int 37, 1203–1206 (2017). https://doi.org/10.1007/s00296-017-3728-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-017-3728-z