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Voltage-gated potassium channel complex antibodies in Creutzfeldt-Jakob disease

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References

  1. Geschwind MD, Tan KM, Lennon VA, Barajas RF Jr, Haman A, Klein CJ, Josephson SA, Pittock SJ (2008) Voltage-gated potassium channel autoimmunity mimicking Creutzfeldt-Jakob disease. Arch Neurol 65:1341–1346

    Article  PubMed  Google Scholar 

  2. Chitravas N, Jung RS, Kofskey DM, Blevins JE, Gambetti P, Leigh RJ, Cohen ML (2011) Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease. Ann Neurol 70:437–444

    Article  PubMed  Google Scholar 

  3. Perry DC, Geschwind MD (2011) Thorough work-up and new diagnostic criteria needed for CJD. Nat Rev Neurol 7:479–480

    Article  PubMed  Google Scholar 

  4. Tomimitsu H, Arimura K, Nagado T, Watanabe O, Otsuka R, Kurono A, Sonoda Y, Osame M, Kameyama M (2004) Mechanism of action of voltage-gated K+ channel antibodies in acquired neuromyotonia. Ann Neurol 56:440–444

    Article  PubMed  CAS  Google Scholar 

  5. Lai M, Huijbers MG, Lancaster E, Graus F, Bataller L, Balice-Gordon R, Cowell JK, Dalmau J (2010) Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 9:776–785

    Article  PubMed  CAS  Google Scholar 

  6. Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A (2010) Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain 133:2734–2748

    Article  PubMed  Google Scholar 

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Acknowledgments

We thank Tetsuyuki Kitamoto, Tohoku University School of Medicine, for analyzing the PRNP, Western blotting of PrPSc, and neuropathology; Katsuya Satoh, Nagasaki University, for 14-3-3 and total tau protein measurement. This work was supported by Grants-in-Aid from the Research Committee of Prion Disease and Slow Virus Infection, the Ministry of Health, Labour and Welfare of Japan, and Health and Labour Sciences Research Grants for Research on Psychiatry and Neurological Diseases and Mental Health (H20-021).

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The authors declare that they have no conflicts of interest.

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Correspondence to Koji Fujita.

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Fujita, K., Yuasa, T., Watanabe, O. et al. Voltage-gated potassium channel complex antibodies in Creutzfeldt-Jakob disease. J Neurol 259, 2249–2250 (2012). https://doi.org/10.1007/s00415-012-6554-y

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  • DOI: https://doi.org/10.1007/s00415-012-6554-y

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