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Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin

  • Original Article—Alimentary Tract
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Abstract

Background

The endoscopic characteristics of gastric ulcers in patients who were using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA) and were infected with Helicobacter pylori remain unclear. We elucidated the endoscopic characteristics of gastric ulcers that occurred in the presence or absence of H. pylori infection and were associated with the use of these drugs.

Methods

A total of 379 patients with active-stage gastric ulcer were divided into three groups: H. pylori-positive patients using neither NSAIDs nor LDA (control group, n = 216), H. pylori-positive or -negative patients using NSAIDs (NSAIDs group, n = 100), and H. pylori-positive or -negative patients using LDA (LDA group, n = 63). The differences among these groups in endoscopic characteristics of the ulcers (site, multiplicity, and morphology) were determined. The influence of an antacid drug, i.e., a proton pump inhibitor (PPI) or a histamine H2 receptor antagonist (H2RA), was also investigated.

Results

The NSAIDs group, regardless of H. pylori infection status, had higher incidences of antral, multiple, and irregularly shaped ulcers. The LDA group had a higher incidence of antral ulcers in H. pylori-negative patients and, regardless of H. pylori infection status, a higher incidence of multiple ulcers. However, the incidence of irregularly shaped ulcers in the LDA group did not differ from that in the control group. Neither the concomitant use of an antacid nor the dosing period of NSAIDs affected the results.

Conclusions

Our study elucidated the morphological characteristics of gastric ulcers in persons taking NSAIDs or LDA in the presence and absence of H. pylori infection. Our results may be clinically useful for inferring the causes of ulcers from their morphological characteristics.

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Acknowledgments

The authors have no conflicts of interest. This study was supported by a research grant from Hyogo College of Medicine.

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Authors and Affiliations

  1. Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Yongmin Kim, Satoko Yokoyama, Jiro Watari, Kazutoshi Hori, Takahisa Yamasaki, Takuya Okugawa, Fumihiko Toyoshima, Takashi Kondo, Jun Sakurai, Junji Tanaka, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui & Hiroto Miwa

  2. Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Takayuki Matsumoto

  3. Department of Gastroenterology, Takarazuka Municipal Hospital, Takarazuka, Japan

    Yongmin Kim & Takashi Abe

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  1. Yongmin Kim
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Corresponding author

Correspondence to Hiroto Miwa.

Additional information

Y. Kim and S. Yokoyama contributed equally to this work.

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Kim, Y., Yokoyama, S., Watari, J. et al. Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin. J Gastroenterol 47, 904–911 (2012). https://doi.org/10.1007/s00535-012-0553-8

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  • DOI: https://doi.org/10.1007/s00535-012-0553-8

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