Abstract
In order to evaluate the clinical significance of Aspergillus-positive culture results from the lower respiratory tract specimens of elderly hospitalized patients, and to identify the clinical variables that differentiate between colonization and infection with Aspergillus spp. in this patient population, a retrospective study was conducted. The records of 66 elderly patients whose lower respiratory tract specimens yielded Aspergillus spp. between January 1995 and July 2000 were examined. The majority of the patients (n=61) were determined to be colonized with Aspergillus spp., and serious lung infection due to Aspergillus spp. was rare. Clinical, radiological, and microbiological data did not help differentiate between infection and colonization.
Similar content being viewed by others
References
Soubani AO, Chandrasekar PH (2002) The clinical spectrum of pulmonary aspergillosis. Chest 121:1988–1999
Strimlan CV, Dines DE, Rodgers-Sullivan RF et al (1980) Respiratory tract Aspergillus: clinical significance. Minn Med 63:25–29
Nalesnik MA, Myerowitz RL, Jenkins R et al (1980) Significance of Aspergillus species isolated from respiratory secretions in the diagnosis of invasive pulmonary aspergillosis. J Clin Microbiol 11:370–376
Treger TR, Visscher DW, Bartlett MS et al (1985) Diagnosis of pulmonary infection caused by Aspergillus: usefulness of respiratory cultures. J Infect Dis 152:572–576
Yu VL, Muder RR, Poorsattar A (1986) Significance of isolation of Aspergillus from the respiratory tract in diagnosis of invasive pulmonary aspergillosis. Results from a three-year prospective study. Am J Med 81:249–254
Horvath JA, Dummer S (1996) The use of respiratory-tract cultures in the diagnosis of invasive pulmonary aspergillosis. Am J Med 100:171–178
Soubani AO, Qureshi MA (2002) Invasive pulmonary aspergillosis following bone marrow transplantation: risk factors and diagnostic considerations. Haematologia 4:427–437
Young RC, Bennett JE, Vogel CL et al (1970) Aspergillosis: the spectrum of the disease in 98 patients. Medicine (Baltimore) 49:147–173
Landi F, Onder G, Gambassi G et al (2000) Body mass index and mortality among hospitalized patients. Arch Intern Med 160:2641–2644
Pagani JJ, Libshitz HI (1981) Opportunistic fungal pneumonias in cancer patients. Am J Roentgenol 137:1033–1039
Kuhlman JE, Fishman EK, Siegelman SS (1985) Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis. Radiology 157:611–614
Caillot D, Casasnovas O, Bernard A et al (1997) Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J Clin Oncol 15:139–147
Roberts CM, Citron KM, Strickland B (1987) Intrathoracic aspergilloma: role of CT in diagnosis and treatment. Radiology 165:123–128
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Soubani, A.O., Khanchandani, G. & Ahmed, H.P. Clinical significance of lower respiratory tract Aspergillus culture in elderly hospitalized patients. Eur J Clin Microbiol Infect Dis 23, 491–494 (2004). https://doi.org/10.1007/s10096-004-1137-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-004-1137-1