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Prediction of severe cardiac involvement by fundus lesion in sarcoidosis

  • Clinical Investigation
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Abstract

Purpose

We examined the relation between ocular sarcoidosis and severe cardiac sarcoidosis necessitating pacemaker implantation.

Methods

In this retrospective, observational, cross-sectional study, we reviewed the clinical records of 108 patients diagnosed with ocular sarcoidosis based on new diagnostic criteria established in Japan. We examined and compared the relationship between fundus findings of ocular sarcoidosis and severe cardiac sarcoidosis necessitating pacemaker implantation.

Results

Of 108 patients with ocular sarcoidosis, seven patients (6.5 %) with median age of 61 years (interquartile range 59–63 years) also had severe heart disease leading to implantation of a pacemaker. Median duration of ocular symptoms was 4.5 years (interquartile range 3.6–7.8 years). Of seven patients with severe cardiac involvement, six had multiple peripheral chorioretinal atrophic lesions (MPCAL), two had nodules in the angle and tent-like peripheral anterior synechia, and two had snowball vitreous opacity. The prevalence of atrophic MPCAL lesions was significantly higher than that of other ocular findings (P < 0.05).

Conclusions

In patients with concurrent ocular sarcoidosis and severe cardiac sarcoidosis, MPCAL atrophic lesions were observed significantly more frequently, suggesting that severe cardiac involvement may be predicted by specific fundus lesions.

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Acknowledgments

We thank Prof. Jun-ichi Sakai for providing clinical information and Ms. Teresa Nakatani for critical revision of the manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Akihiko Umazume, Takeshi Kezuka, Yoko Okunuki, Masayo Ooshita, Yoshihiko Usui & Hiroshi Goto

  2. Department of Cardiovascular Medicine, Tokyo Medical University, Tokyo, Japan

    Masaharu Hirano & Akira Yamashina

Authors
  1. Akihiko Umazume
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  2. Takeshi Kezuka
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  3. Yoko Okunuki
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  4. Masayo Ooshita
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  5. Yoshihiko Usui
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  6. Masaharu Hirano
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  7. Akira Yamashina
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  8. Hiroshi Goto
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Corresponding author

Correspondence to Takeshi Kezuka.

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Umazume, A., Kezuka, T., Okunuki, Y. et al. Prediction of severe cardiac involvement by fundus lesion in sarcoidosis. Jpn J Ophthalmol 58, 81–85 (2014). https://doi.org/10.1007/s10384-013-0288-y

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  • DOI: https://doi.org/10.1007/s10384-013-0288-y

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