Correction of fructosamine value for serum albumin and globulin concentrations
References (18)
- et al.
Determination of serum proteins by means of the buret reaction
J. Biol. Chem.
(1949) - et al.
Albumin standards and the measurement of serum albumin with brom cresol green
Clin. Chim. Acta
(1971) - et al.
A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography
Metabolism
(1978) - et al.
Inorganic phosphate accelerates hemoglobin A1c synthesis
Life Sci.
(1989) - et al.
Fructosamine: A new approach to the estimation of serum glycosylprotein. An index of diabetic control
Clin. Chim. Acta.
(1982) - et al.
Serum fructosamine in patients with diabetes mellitus
N.Z. Med. J.
(1985) - et al.
Evaluation of fructosamine test for measurement of plasma protein glycation
Diabetologia
(1987) - et al.
Plasma fructosamine is a measure of all glycated proteins
Clin. Chem.
(1986) - et al.
Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus
Br. Med. J.
(1983)
Cited by (13)
Diabetes mellitus in chronic kidney disease: Biomarkers beyond HbA1c to estimate glycemic control and diabetes-dependent morbidity and mortality
2020, Journal of Diabetes and its ComplicationsCitation Excerpt :For this reason, changes in immunoglobulin levels –particularly IgA- can disturb glycemic monitorization by FA and the relationship between changes in immunoglobulin levels and FA should be better characterized in DM patients. To overcome artifacts in glycemic control monitoring by FA caused by changes in serum protein levels, correcting FA values by albumin alone would not suffice146 and alternative formulas which include globulin levels alongside albumin would be required.147 Increased protein carbamylation in CKD can also suppress FA formation by competing with protein glycation.148
Applications and pitfalls of hemoglobin A1C and alternative methods of glycemic monitoring
2020, Journal of Diabetes and its ComplicationsCitation Excerpt :Without adjustment, lower fructosamine values are expected in hypoalbuminemia, even at the same blood glucose levels. Multiple equations have been proposed to correct for variations in albumin, but the simplest for practical application is multiplying the measured fructosamine by the ratio of normal albumin of 4 g/L over the measured albumin in g/L.38 Studies have shown that there is good correlation between fructosamine, A1C, and fasting blood glucoses.37,39
Effect of Ramadan fasting on renal function in patients with type 2 diabetes
2019, Diabetes Research and Clinical PracticeCitation Excerpt :Reduction in serum albumin lowers the serum fructosamine value [9]. A correction equation for fructosamine: FRAc = FRA × 4 (Alb) [10]. Quantitative determination of albumin in urine was done using Enzyme Immunoassay.
Physiologic concentrations of inorganic phosphate accelerate fructosamine synthesis
1992, Diabetes Research and Clinical PracticeA comparative analysis of fructosamine with other risk factors for kidney dysfunction in diabetic patients with or without chronic kidney disease
2019, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :Fructosamine is not affected by any haemoglobin metabolism disorder but in protein turnover. Fructosamine concentration mainly depends on the concentration of each serum protein because it is generated from non-enzymatic glycation of mainly albumin (∼90%) and various proteins [10]. This correlation based study was designed to investigate the significance of serum fructosamine in the development of chronic kidney disease in diabetic patients and to associate clinical relationship of serum fructosamine with other risk factors of diabetic nephropathy.