Sennosides do not kill myenteric neurons in the colon of the rat or mouse
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Cited by (46)
Evaluation and Treatment of Constipation in the Geriatric Population
2021, Clinics in Geriatric MedicineCitation Excerpt :Side effects include abdominal cramping, distention, nausea, and diarrhea. Although long-term use of stimulant laxatives that contain anthraquinone, such as senna, can cause melanosis coli, they do not seem to impair the enteric nervous system based on studies in animal models.32,33 This knowledge should be used to dispel the notion that chronic use of these agents causes nerve damage and worsening constipation.
Chronic Constipation
2019, Mayo Clinic ProceedingsCitation Excerpt :In a large study, sodium picosulfate improved stool consistency and frequency as well as ease of evacuation and quality of life compared with placebo.92 Stimulant laxatives do not appear to damage the enteric nervous system.106,107 Unfortunately, it remains common for physicians and pharmacists to warn of the “potential dangers” of using stimulant laxatives, which may lead to underutilization of these effective and inexpensive agents.
Neurophysiologic Mechanisms of Human Large Intestinal Motility
2018, Physiology of the Gastrointestinal Tract, Sixth EditionEffectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation
2017, Journal of Pediatric SurgeryCitation Excerpt :However, this had not been validated before in a clinical trial. In our extensive literature review prior to this study, we could not find relevant toxicity reports for Senna laxatives [17–19]. We decided to use a randomized controlled crossover design clinical trial because the patients are their own control group.
Inpatient constipation
2015, Hospital Medicine ClinicsCitation Excerpt :Bisacodyl may thus be an option for those patients who are not able to tolerate anything by mouth, but may only be effective for patients in whom stool has reached the rectal vault or the left side of the colon. Prior literature suggested that long-term use of these medications damages the colonic nervous system; however, recent studies have refuted this claim.33 Enemas are liquid suspensions that act by softening stool and stimulating the rectum when introduced into the rectum.
Functional problems and their medical management
2013, Colorectal Surgery, Fifth Edition