Cutaneous manifestations of Crohn's disease

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Crohn's disease is a chronic inflammatory bowel disease which may have distinctive mucocutaneous manifestations. Included in this group are perianal, peristomal, and perifistular ulceration, as well as granulomatous cutaneous inflammation separate from gastrointestinal tract openings (metastatic Crohn's disease). In the oral cavity, both ulcerations and granulomatous nodules may occur. Malabsorption of nutrients may lead to several changes, including an acrodermatitis enteropathica–like syndrome secondary to zinc deficiency. Patients with Crohn's disease may also have pyoderma gangrenosum, erythema nodosum, cutaneous vasculitis, and other less specific changes.

References (61)

  • JW Singleton et al.

    Adverse reactions to study drugs

    Gastroenterology

    (1979)
  • BB Crohn et al.

    Regional ileitis

    JAMA

    (1932)
  • MH Samitz et al.

    Cutaneous vasculitis in association with Crohn's disease

    Cutis

    (1970)
  • HE Lockhart-Mummery et al.

    Crohn's disease of the large intestine

    Gut

    (1964)
  • H Eissner

    Lymphoedema chronicum penis et scroti bei Enteritis regionalis

    Arch Klin Exp Dermatol

    (1960)
  • JL Verbov

    The skin in patients with Crohn's disease and ulcerative colitis

    Trans St Johns Hosp Dermatol Soc

    (1973)
  • BK Gray et al.

    Crohn's disease of the anal region

    Gut

    (1965)
  • H Krieg et al.

    Anale and perianale Komplikationen beim Morbus Crohn

    München Med Wochenschr

    (1977)
  • JC Mountain

    Cutaneous ulceration in Crohn's disease

    Gut

    (1970)
  • DI McCallum et al.

    Metastatic Crohn's disease

    Br J Dermatol

    (1976)
  • AG Parks et al.

    Crohn's disease with cutaneous involvement

    Proc R Soc Med

    (1965)
  • JA Witkowski et al.

    Crohn's disease—non-caseating granulomas on the legs

    Acta Derm Venereol (Stockh)

    (1977)
  • Burgdorf WH, Orkin M: Granulomatous vasculitis in Crohn's disease. Arch Dermatol. (In...
  • A Wagner

    Hauterkrankungen bei Enteritis regionalis (Morbus Crohn)

    Dtsch Med Wochenschr

    (1971)
  • MA Issa

    Crohn's disease of the mouth

    Br Dent J

    (1971)
  • A Kint et al.

    Cheilitis granulomatosa and Crohnsche Krankheit

    Hautarzt

    (1977)
  • CB Croft et al.

    Ulceration of the mouth, pharynx, and larynx in Crohn's disease of the intestine

    Br J Surg

    (1972)
  • J Kyle
  • MK Basu et al.

    Oral manifestations of Crohn's disease

    Gut

    (1975)
  • AJ Greenstein et al.

    The extra-intestinal complications of Crohn's disease and ulcerative colitis: A study of 700 patients

    Medicine

    (1976)
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