Original articlesAbnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
Section snippets
IBS patients and healthy controls
Thirty patients who met the Rome II criteria for IBS23 and who had completed a full negative evaluation for other diseases in the University Hospital, Nottingham Gastroenterology Outpatient Clinic were included. Over the duration of the study 133 IBS patients were seen. After applying the exclusions listed later there were 51 eligible patients, of whom 30 chose to take part. The most common reason for not participating was inability to take time off from work. The evaluation included a detailed
Demographics and bowel symptoms
The age range within each of the 3 groups was similar (range, 18–59 y) and there were no significant differences among the groups. As shown, C-IBS patients had less frequent, harder stools whereas the PI-IBS patients had more frequent, looser stools, but the frequency of abdominal pain was similar in both IBS groups (P = .4) (Table 1). There were significantly more men in the PI-IBS group and, consequently, the mean weight was highest in this group. There was a trend for bloating to be more
Discussion
This study directly compared postprandial 5-HT release and mucosal 5-HT metabolism in various subtypes of IBS. Our most significant finding was uniformly decreased postprandial levels of plasma 5-HT in C-IBS patients. This decreased release was associated with significantly delayed transit. In an attempt to define the causes of this decreased release we examined mucosal EC cells within a rectal biopsy specimen. We found that C-IBS patients tended to have increased amounts of 5-HT per cell when
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