Clinical InvestigationsPrevention and RehabilitationDistribution of creatine kinase in the general population: Implications for statin therapy
Section snippets
Methods
Reference intervals were determined according to the guidelines of the Nordic Reference Interval Project and the Clinical Laboratory Standards Institute (CLSI, formerly the National Committee on Clinical Laboratory Standards [NCCLS]).13., 14.
Results
We obtained serum CK activities from 1444 citizens, aged 34 to 60 years, 503 of white European, 292 of South Asian, 580 of African, and 69 of other ancestry.
Discussion
To our knowledge, this is the first report on reference intervals for serum CK activity based on a random sample of the general population, including subjects of different ancestry, and standardizing for exercise. Our data suggest that relatively high CK activities commonly occur in the general population, including in people of European, South Asian, and African ancestry, and even after 3 days of rest.
The calculated upper reference limit in the total group as well as the limits in the
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