MiscellaneousFrequency and Impact of Pulmonary Hypertension in Patients With Obstructive Sleep Apnea Syndrome
Section snippets
Methods
The institutional review board at the Cleveland Clinic approved the study. Patients undergoing pulmonary artery catheterization within 6 months of overnight polysomnography (for evaluation of OSA because of symptoms) who showed evidence of OSA (as defined below) were included in the present study. Data regarding demographics, polysomnographic variables, hemodynamics (as determined using transthoracic echocardiography and pulmonary artery catheterization), and pulmonary function were recorded by
Results
A total of 83 patients with complete polysomnographic and pulmonary artery catheterization data were analyzed (Figure 1). Patients tended to be middle-age, overweight men (Table 1). Most patients had mild or moderate OSA and a moderate restriction on their pulmonary function tests. No significant differences between the PH and non-PH groups were observed regarding age or apnea-hypopnea index (Table 1). Despite the male preponderance in the overall population, more female than male patients had
Discussion
The present study represents the first report on pulmonary hemodynamics in patients with OSA to use the currently accepted definition of a mean pulmonary arterial pressure at rest >25 mm Hg to define PH.15, 16 Our results extend the sparse data suggesting that PH confers functional limitations and a poor prognosis in patients with OSA. Our study has also shown that a significant proportion of patients with OSA undergoing pulmonary artery catheterization might have PH, which could be
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2023, Biomedicine and PharmacotherapyCitation Excerpt :Although a few cardiovascular effects, including hypertension, congestive cardiovascular breakdown, and arrhythmias, are better perceived, little is known about the association between OSA and pulmonary hypertension (PH) [2]. While available studies suggest that the prevalence of PH in patients diagnosed with OSA ranges from 17% to 70% [3–5], a few recent studies have provided important insights into the association of PH with impaired physical functioning and health-related quality of life [6]. Intermittent hypoxia (IH) is an essential contributor in the pathogenesis of OSA, which can lead to PH and other cardiovascular diseases.