Arrhythmias and conduction disturbancesPredictors of Mortality in Patients With Cardiovascular Implantable Electronic Device Infections
Section snippets
Methods
We retrospectively reviewed all patients with CIED infection who were admitted to Mayo Clinic (Rochester, Minnesota) from January 1, 1991 to December 31, 2008. The cases of CIED infection were identified from the Mayo Clinic Heart Rhythm Device Database, the surgical index, and the computerized central diagnostic index.5 The Mayo Clinic institutional review board reviewed and approved the study proposal.
CIED infection was defined using criteria previously described by our group.2, 5, 6 Cases of
Results
Overall, 415 patients with CIED infection were identified from January 1, 1991 to December 31, 2008. The clinical patient characteristics are summarized in Table 1. Of the 415 patients, 1 patient who was alive at hospital discharge was excluded from the analysis of short-term mortality because the 30-day follow-up data were not available. Of the remaining 414 patients, 23 (5.6%) died within 30 days after admission and 391 (94.4%) were alive at 30 days after admission. The univariate
Discussion
Our investigation is one of the largest to analyze the risk factors associated with short- and long-term mortality in patients with CIED infection. Moreover, using data from our multivariate models, we devised a simple and an easy-to-use prediction tool for short-term mortality (Table 3) that includes readily available clinical information, such as the presence or absence of heart failure, history of corticosteroid therapy, and echocardiographic evidence of CIED-IE. We believe this model will
Acknowledgment
We thank Joanne E. Spencer, RN, and Nancy Acker, RN, for their important contributions in data collection.
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2020, European Journal of Internal MedicineCitation Excerpt :CIED infections carry a significant risk of morbidity and the eradication of infection requires the complete removal of the device and all lead materials, with related risks due to surgical or transvenous extractions [20–24]. These infections showed in-hospital mortality of 2–5% and one-year mortality of approximately 20% [25–26]. The Shariff score was prospectively tested in a multicenter study on patients with CIED infection referred for a transvenous lead extraction.
This work was supported by a Career Development Award to Dr. Sohail from the Department of Medicine, Mayo Foundation for Medical Education and Research (Rochester, Minnesota).
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