Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women
Section snippets
Patients
Obese (BMI>30) premenopausal women aged 20–46 years were recruited from the outpatient Department for Weight Loss in the teaching hospital at the Second University of Naples, Italy. Exclusion criteria were type 2 diabetes mellitus, hypertension (blood pressure >140/90 mmHg), cardiovascular disease, history of alcohol abuse (intake of >500 g/week in the last year), and any medication use. Thus the obese women satisfied the criteria for successful liposuction surgery, that is healthy individuals
Results
The characteristics of the women who took part in the study are shown in Table 1. All women were premenopausal, with BMI values ranging from 30 to 45. Compared with nonobese women, obese women had higher values of WHR, fasting glucose and insulin concentrations, and HOMA. Serum IL-6, IL-18, TNF-α and CRP levels were higher, while adiponectin levels were lower in the obese group than in the nonobese group. Spearman rank correlation coefficients showed positive associations between circulating
Discussion
This is the first study to assess prospectively the effect of liposuction on metabolic parameters and markers of vascular inflammation in obese women. The data presented show that an amount of fat aspirate between 2 and 3 l is safe and associated with improvement of some metabolic (insulin resistance) and inflammatory (cytokines and CRP) markers.
The vascular inflammatory markers that improved after liposuction are linked to future thrombotic events through mechanisms of atherosclerotic plaque
Acknowledgements
This work was supported, in part, by an University Research Grant of the Second University of Naples, Italy.
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