Original article—alimentary tractDiagnostic Accuracy of Capsule Endoscopy for Small Bowel Crohn's Disease Is Superior to That of MR Enterography or CT Enterography
Section snippets
Materials and Methods
This prospective, blinded, multicenter study recruited patients from 4 centers managing adult patients with inflammatory bowel diseases (http://ClinicalTrials.gov Identifier NCT01019460). Patients were recruited during a 22-month period starting October 2007. All patients had a standardized work-up including medical history, physical examination, blood and stool samples, and ileocolonoscopy. MRE and CTE were performed on the same day at a single center. Subsequently, CE was performed in
Results
A total of 104 patients were included in the study (Figure 1). Eleven patients were excluded before small bowel examinations; 9 patients withdrew their consent for participation, 1 patient was admitted to the hospital and underwent acute examinations, and 1 patient was unable to complete both MRE and CTE and was excluded. Characteristics of 93 patients examined in the study protocol are shown in Table 1.
On the basis of symptoms, clinical, and biochemical findings and the result of
Discussion
Still today, CD is a syndrome diagnosis based on the clinical presentation and findings at endoscopy, histology, and small bowel radiology.12 For assessing the small intestine, small bowel follow-through and enteroclysis are challenged by new cross-sectional imaging modalities and endoscopic methods and are no longer generally accepted as gold standards.10, 12 Studies evaluating and comparing new modalities are needed to establish the optimal diagnostic strategies in patient subgroups.
In the
Acknowledgments
Many thanks to the following colleagues for participation in this study: Troels Havelund, PhD, Dr Benedicte Wilson, Jane Møller Hansen, PhD, Dr Laurits Laursen, Dr Finn Møller Pedersen, Professor Ove B. Schaffalitzky de Muckadell, DMSci, and Karsten Lauritsen, DMSci, Department of Medical Gastroenterology, Odense University Hospital, Denmark; Dr Anette Hygum Knudsen, Dr Ejler Ejlersen, Bent Nyboe Andersen, DMSci, and Henrik Hey, DMSci, Department of Internal Medicine, Section of
References (21)
- et al.
Abdominal MRI after enteroclysis or with oral contrast in patients with suspected or proven Crohn's disease
Clin Gastroenterol Hepatol
(2004) - et al.
Capsule endoscopy versus enteroclysis in the detection of small-bowel involvement in Crohn's disease: a prospective trial
Clin Gastroenterol Hepatol
(2005) - et al.
Capsule endoscopy findings in patients with established and suspected small-bowel Crohn's disease: correlation with radiologic, endoscopic, and histologic findings
Gastrointest Endosc
(2005) - et al.
Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease
Clin Gastroenterol Hepatol
(2004) - et al.
Sample size calculation should be performed for design accuracy in diagnostic test studies
J Clin Epidemiol
(2005) - et al.
The second European evidence-based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis
Journal of Crohn's and Colitis
(2010) - et al.
Role of MRI in Crohn's disease
Clin Radiol
(2009) - et al.
Comparison of MR enteroclysis with MR enterography and conventional enteroclysis in patients with Crohn's disease
Eur Radiol
(2008) - et al.
Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis
Eur Radiol
(2006) - et al.
Prevalence of penetrating disease and extraintestinal manifestations of Crohn's disease detected with CT enterography
Inflamm Bowel Dis
(2008)
Cited by (208)
Serum food specific IgG antibodies are associated with small bowel inflammation in patients with Crohn’s disease
2024, European Journal of Clinical NutritionVideo Capsule Endoscopy can Identify Occult Luminal Crohn's Disease in Patients with Isolated Perianal Fistulas
2023, Journal of Crohn's and ColitisMulticenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn’s disease in Japan (SPREAD-J study)
2023, Journal of GastroenterologyPatency Capsule: A Novel Independent Predictor for Long-Term Outcomes among Patients with Quiescent Crohn's Disease
2023, American Journal of Gastroenterology
Conflicts of interest The authors disclose no conflicts.