Irreversible encephalopathy after treatment with high-dose intravenous metronidazole
References (16)
- et al.
Reversible metronidazole-induced encephalopathy
J Neuroradiol.
(2007) - et al.
Metronidazole-induced encephalopathy
J Neurol Sci.
(2004) - et al.
Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: A prospective randomized trial
J Pediatr Surg.
(2008) - et al.
Evaluation of metronidazole toxicity: A prospective study
Int J Clin Pharmacol Res.
(1999) - et al.
Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess
Dig Dis Sci.
(2006) - et al.
Intravenous metronidazole for treatment of infections involving anaerobic bacteria
Antimicrob Agents Chemother.
(1982) - et al.
Acute encephalopathy associated with metronidazole therapy
Afr J Med Med Sci.
(1997) - et al.
Metronidazole-induced encephalopathy and inferior olivary hypertrophy: Lesion analysis with diffusion-weighted imaging and apparent diffusion coefficient maps
Arch Neurol.
(2003)
Cited by (38)
Metronidazole-induced encephalopathy in a patient with cirrhosis
2024, Radiology Case ReportsA potential new role for ASL perfusion imaging: Diagnosis of metronidazole induced encephalopathy – Two companion cases
2020, Radiology Case ReportsCitation Excerpt :When administered in high dosages, generally 1.5 g/day or higher or for long periods, this medication can rarely induce an encephalopathy (MIE) characterized by altered mental status, gait abnormalities, dysarthria, extremity weakness in addition to other findings. Although most often reversible after medication cessation, there have been reports of irreversible encephalopathy as well. [17],[5],[18] The incidence of MIE is still unknown but generally considered rare. [2]
Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge
2016, Journal of Emergency MedicineCitation Excerpt :Therefore, it is preferable to keep the cumulative dose of metronidazole to < 20 g, especially in cirrhotic and real dysfunction patients. If not recognized early, MIE can be lethal due to progressive toxic encephalopathy (13). Brain imaging (MRI) typically shows characteristic symmetrical lesions in the cerebellar region near the dentate nuclei, as seen in this case.
An 82-year-old man with ataxia and dysarthria
2016, CMAJCitation Excerpt :Most reported cases of metronidazole-induced encephalopathy have had good outcomes with resolution of signs, symptoms and MRI findings after drug cessation. Although the prognosis appears to be favourable overall, there are two case reports in which metronidazole-induced encephalopathy contributed to death,10,11 emphasizing the importance of timely recognition of a condition that is largely reversible. This case highlights a rare adverse effect of a commonly prescribed medication.
A case report of metronidazole-induced encephalopathy in a bowel obstruction patient with MRI findings
2023, SAGE Open Medical Case Reports