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The late menopause transition (when women begin to experience 60 or more days of amenorrhea) is the point in time when hot flashes, adverse mood, vaginal dryness, and sleep complaints accelerate in prevalence.
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The duration of hot flashes (vasomotor symptoms) maybe longer than previously thought, with newer studies indicating durations of as long as 10 or more years.
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There are nonestrogenic alternatives that are now approved by the US Food and Drug Administration (FDA) for the treatment of
Endocrinology and Metabolism Clinics of North America
Menopausal Symptoms and Their Management
Section snippets
Key points
Epidemiology
Population-based, epidemiologic studies of menopausal women have recently been conducted and are yielding reliable and consistent information about the incidence, prevalence, and severity of several menopausal symptoms. However, the field is relatively new, and it is likely that there are subsets of women who are more or less vulnerable to particular symptoms or sets of symptoms. In 2005, a state-of-the-science conference on menopausal symptoms was convened, with a worldwide panel of expert
Summary
The menopausal transition and postmenopausal years are associated with significant symptoms. Vasomotor symptoms and adverse mood often demonstrate improvement after a woman is postmenopausal, whereas sleep complaints, vaginal dryness/dyspareunia, and cognitive complaints tend to persist or worsen in association with aging. There is evidence that the changing hormone milieu, with significant changes in estrogen levels, can affect the brain systems involved in mood and cognition. Patients often
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N. Santoro has investigator-initiated grant support from Bayer and stock options in Menogenix. C.N. Epperson and S.B. Matthews have nothing to disclose.