Elsevier

Journal of Infection

Volume 80, Issue 6, June 2020, Pages 607-613
Journal of Infection

Review
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

https://doi.org/10.1016/j.jinf.2020.03.037Get rights and content

Summary

Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the mortality is high. Some evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, severe deterioration in some patients has been closely associated with dysregulated and excessive cytokine release. This article reviews what we know of the mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in an attempt to provide some background to inform future guidance for clinical treatment.

Keywords

Coronavirus
2019-nCoV
SARS-CoV-2
Cytokine storm
Immunomodulation

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