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Cryptosporidium infections: molecular advances

Published online by Cambridge University Press:  28 March 2014

MATTHIAS LENDNER*
Affiliation:
Institute for Parasitology, An den Tierkliniken 35, 04103 Leipzig, Germany
ARWID DAUGSCHIES
Affiliation:
Institute for Parasitology, An den Tierkliniken 35, 04103 Leipzig, Germany
*
*Corresponding author: Matthias Lendner, Institut für Parasitologie, An den Tierkliniken 35, 04103 Leipzig, Germany. E-mail: matthias.lendner@vetmed.uni-leipzig.de

Summary

Cryptosporidium host cell interaction remains fairly obscure compared with other apicomplexans such as Plasmodium or Toxoplasma. The reason for this is probably the inability of this parasite to complete its life cycle in vitro and the lack of a system to genetically modify Cryptosporidium. However, there is a substantial set of data about the molecules involved in attachment and invasion and about the host cell pathways involved in actin arrangement that are altered by the parasite. Here we summarize the recent advances in research on host cell infection regarding the excystation process, attachment and invasion, survival in the cell, egress and the available data on omics.

Type
Special Issue Article
Copyright
Copyright © Cambridge University Press 2014 

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References

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