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Severe Sinus Bradycardia after Initiation of Bupropion Therapy: A Probable Drug-Drug Interaction with Metoprolol

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Abstract

Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.

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References

  1. Guzey C, Norstrom A, Spigset O. Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion. Therapeutic Drug Monitoring 2002;24:436–437.

    Google Scholar 

  2. Shad MU, Preskorn SH. A possible bupropion and imipramine interaction. J Clin Psychopharmacol 1997;118- 119.

    Google Scholar 

  3. Nemeroff CB, Delane CL, Pollock BG. Newer antidepressants and the cytochrome P450 system. Am J Psychiatry 1996;153:311–320.

    Google Scholar 

  4. Edeki TI, He H, Wood AJJ. Pharmacogenetic explanation for excessive B-blockade following timolol eye drops: Potential for oral-ophthalmic drug interaction. JAMA 1995;274:1611- 1613.

    Google Scholar 

  5. Dinai Y, Mordechar S, Haveh N, Halkin H. Bradycardia induced by interaction between quinidine and ophthalmic tim-olol. Ann Intern Med 1985;103:890–891.

    Google Scholar 

  6. Weinshilboum R. Inheritance and Drug Response. NEngl J Med 2003;348:529–537.

    Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, The University of Texas-Southwestern Medical Center at Dallas, Dallas, Texas, U.S.A

    David L. McCollum & Darren K. McGuire

  2. Department of Clinical Pharmacy, Dallas VA Medical Center, Dallas, Texas, U.S.A

    Jerica L. Greene

  3. The Donald W. Reynolds Cardiovascular Clinical Research Center at UT-Southwestern, Dallas, Texas, U.S.A

    Darren K. McGuire

Authors
  1. David L. McCollum
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  2. Jerica L. Greene
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  3. Darren K. McGuire
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McCollum, D.L., Greene, J.L. & McGuire, D.K. Severe Sinus Bradycardia after Initiation of Bupropion Therapy: A Probable Drug-Drug Interaction with Metoprolol. Cardiovasc Drugs Ther 18, 329–330 (2004). https://doi.org/10.1023/B:CARD.0000041254.15807.98

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  • DOI: https://doi.org/10.1023/B:CARD.0000041254.15807.98

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