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Co-localization of corticotropin releasing factor and vasopressin mRNA in neurones after adrenalectomy

Nature volume 315, pages 59–61 (1985)Cite this article

Abstract

The discrete anatomical distribution of arginine vasopressin and corticotropin releasing factor (CRF) immunoreactivity in the para-ventricular nucleus (PVN) of the rat hypothalamus is altered after adrenalectomy1–3. Not only is the immunostaining of both peptides enhanced, but vasopressin immunoreactivity, normally confined to the magnocellular subdivision, becomes clear in a large percentage of CRF neurones in the parvocellular subdivision2. These changes in immunoreactivity may reflect changes in post-translational events, peptide metabolism or genomic activity that lead indirectly or directly to the enhanced expression of vasopressin. Here we report that levels of transcripts homologous to vasopressin messenger RNA increase in the PVN after adrenalectomy, in parallel with increases in vasopressin immunoreactivity. In fact, after adrenalectomy, vasopressin mRNA can be detected in CRF-immunoreactive neurones. These results indicate that a considerable degree of plasticity is retained by the adult neuronal genome of the rat and that this plasticity may be modulated by the endocrine environment.

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Authors and Affiliations

  1. Central Research & Development Department, Experimental Station, E. I. du Pont de Nemours & Co., Wilmington, Delaware, 19898, USA

    Betty Wolfson, Robert W. Manning, Leonard G. Davis, Rene Arentzen & Frank Baldino Jr

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  1. Betty Wolfson
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  4. Rene Arentzen
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  5. Frank Baldino Jr
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Wolfson, B., Manning, R., Davis, L. et al. Co-localization of corticotropin releasing factor and vasopressin mRNA in neurones after adrenalectomy. Nature 315, 59–61 (1985). https://doi.org/10.1038/315059a0

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