Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

Abstract

Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Collier, H. O. J., Adv. Pharmacol. Chemother., 7, 333 (1969).

    Article  CAS  Google Scholar 

  2. Collier, H. O. J., Nature, 223, 35 (1969).

    Article  CAS  Google Scholar 

  3. Collier, H. O. J., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 15, 601 (1960).

    Article  CAS  Google Scholar 

  4. Collier, H. O. J., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 20, 345 (1963).

    Article  CAS  Google Scholar 

  5. Berry, P. A., and Collier, H. O. J., Brit. J. Pharmacol. Chemother., 23, 201 (1964).

    Article  CAS  Google Scholar 

  6. Collier, H. O. J., James, G. W. L., and Schneider, C., Nature, 212, 411 (1966).

    Article  CAS  Google Scholar 

  7. Jacques, R., Helv. Physiol. Pharmacol. Acta, 23, 156 (1965).

    Google Scholar 

  8. Berry, P. A., thesis, Council for National Academic Awards, London, 91 (1966).

  9. Collier, H. O. J., and Sweatman, J. F., Nature, 219, 864 (1968).

    Article  CAS  Google Scholar 

  10. Piper, P. J., and Vane, J. R., Nature, 223, 29 (1969).

    Article  CAS  Google Scholar 

  11. Piper, P. J., and Vane, J. R., in Prostaglandins, Peptides and Amines (edit. by Mantegazza, P., and Horton, E. W.), 15 (Academic Press, London, 1969).

    Google Scholar 

  12. Vargaftig, B. B., and Dao, N., Pharmacology (in the press).

  13. Piper, P. J., and Vane, J. R., in Prostaglandins (edit. by Ramwell, P., and Shaw, J.) (NY Acad. Sci., in the press, 1971).

    Google Scholar 

  14. Ånggård, E., and Samuelsson, B., J. Biol. Chem., 240, 3518 (1965).

    PubMed  Google Scholar 

  15. Ferreira, S. H., and Vane, J. R., Nature, 216, 868 (1967).

    Article  CAS  Google Scholar 

  16. Vane, J. R., Brit. J. Pharmacol. Chemother., 12, 344 (1957).

    Article  CAS  Google Scholar 

  17. Regoli, D., and Vane, J. R., Brit. J. Pharmacol. Chemother., 23, 351 (1964).

    Article  CAS  Google Scholar 

  18. Gaddum, J. H., Brit. J. Pharmacol. Chemother., 8, 321 (1953).

    Article  CAS  Google Scholar 

  19. Gilmore, N., Vane, J. R., and Wyllie, J. H., Nature, 218, 1135 (1968).

    Article  CAS  Google Scholar 

  20. Gréen, K., and Samuelsson, B., J. Lipid Res., 5, 117 (1964).

    PubMed  Google Scholar 

  21. Willis, A. L., Brit. J. Pharmacol., 40, 583P (1970).

    CAS  Google Scholar 

  22. Milton, A. S., and Wendlandt, S. J., J. Physiol., 207, 76P (1970).

    CAS  PubMed  Google Scholar 

  23. Feldberg, W., and Saxena, P. N., J. Physiol. (in the press, 1971).

  24. Willis, A. L., in Prostaglandins, Peptides and Amines (edit. by Mantegazza, P., and Horton, E. W.), 31 (Academic Press, London, 1969).

    Google Scholar 

  25. Greaves, M. W., Søndergaard, J., and McDonald-Gibson, W., Brit. Med. J., 2, 258 (1911).

    Article  Google Scholar 

  26. Crunkhorn, P., and Willis, A. L., Brit. J. Pharmacol., 41, 49 (1971).

    Article  CAS  Google Scholar 

  27. Bergström, S., Carlson, L. A., and Weeks, J. R., Pharmacol. Rev., 20, 1 (1968).

    PubMed  Google Scholar 

  28. Collier, H. O. J., Nature (in the press).

  29. James, G. W. L., J. Pharm. Pharmacol., 21, 379 (1969).

    Article  CAS  Google Scholar 

  30. Goodman, L. S., and Gilman, A., The Pharmacological Basis ofTherapeutics, fourth ed. (Collier-Macmillan, London, 1970).

    Google Scholar 

  31. Hucker, H. B., Zacchei, A. G., Cox, S. V., Brodie, D. A., and Cantwell, N. H. R., J. Pharmac. Exp. Therap., 153, 237 (1966).

    CAS  Google Scholar 

  32. Nugteren, D. H., Beerhuis, R. K., and Van Dorp, D. A., Reel. Trav. Chim. Pays-Bas Belg., 85, 405 (1966).

    Article  CAS  Google Scholar 

  33. Karim, S. M. M., Brit. Med. J., 4, 618 (1968).

    Article  CAS  Google Scholar 

  34. Chaudhuri, G., Lancet, i, 480 (1971).

  35. Smith, J. B., and Willis, A. L., Nature New Biology, 231, 235 (1971).

    Article  CAS  Google Scholar 

  36. Ferreira, S. H., Moncada, S., and Vane, J. R., Nature New Biology, 231, 237 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

VANE, J. Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs. Nature New Biology 231, 232–235 (1971). https://doi.org/10.1038/newbio231232a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio231232a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing