Original InvestigationMortality in Incident Maintenance Dialysis Patients Versus Incident Solid Organ Cancer Patients: A Population-Based Cohort
Section snippets
Design and Setting
We conducted a population-based cohort study using administrative health care databases from Ontario, Canada, held at the ICES. These data sets were linked using unique encoded identifiers and analyzed at ICES. The use of data in this project was authorized under section 45 of Ontario’s Personal Health Information Protection Act (PHIPA), which does not require review by a Research Ethics Board. ICES is a designated prescribed entity under Section 45 of the PHIPA. Participant informed consent
Baseline Characteristics
We identified 33,500 maintenance dialysis patients (women, n = 13,587 [40.6%] and men, n = 19,913 [59.4%]) and 532,452 patients with cancer (women, n = 256,938 [48.3%]; men, n = 275,514 [51.7%]; Fig S1). Baseline characteristics for women on maintenance dialysis therapy and women with breast, lung, colorectal, or pancreas cancer are shown in Table 1, while baseline characteristics for men on maintenance dialysis therapy and men with prostate, lung, colorectal, or pancreas cancer are presented
Discussion
In this study, we found that survival in maintenance dialysis patients was lower than that for patients with several types of cancer. Specifically, maintenance dialysis patients had a better short- and long-term probability of survival compared with patients with pancreas and lung cancer, but poorer survival compared with patients with colorectal cancer (5- and 10-year survival) and breast and prostate cancer, for women and men, respectively. However, when we examined survival by age, women and
Article Information
Authors’ Full Names and Academic Degrees
Kyla L. Naylor, PhD, S. Joseph Kim, MD, PhD, Eric McArthur, MSc, Amit X. Garg, MD, PhD, Megan K. McCallum, MPH, and Gregory A. Knoll, MD, MSc.
Authors’ Contributions
Research idea and study design: KLN, SJK, EM, GAK; data analysis/interpretation: all authors; statistical analysis: EM; supervision or mentorship: SJK, GAK. Each author contributed important intellectual content during manuscript drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or
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K.L.N. and S.J.K. contributed equally to this work.