Original ResearchFull Report: Clinical—Alimentary TractDiet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial
Section snippets
Subjects
For this multi-center, parallel, randomized, controlled, single-blind, comparative trial, we recruited adult patients (18−70 years of age) meeting Rome III criteria for IBS2 from the gastroenterology outpatient clinics of Sahlgrenska University Hospital, Gothenburg; Karolinska University Hospital, Stockholm; and Sabbatsbergs Hospital, Stockholm. In Gothenburg, patients were also recruited through advertisement in the local newspaper. Exclusion criteria were presence of a severe cardiac, liver,
Subjects
Eighty-four patients entered the screening period of the study (mean age 42.5 [SD 16.3] years; 66 females) (Sahlgrenska University Hospital, n = 70; Karolinska University Hospital, n = 9; Sabbatsbergs Hospital, n = 5). There were 9 screening failures (mean age 44.0 [SD 17.1] years; 5 females) (Sahlgrenska University Hospital, n = 8; Karolinska University Hospital, n = 0; Sabbatsbergs Hospital, n = 1), which were not randomized because they did not fulfill the randomization criterion of IBS-SSS
Discussion
In this study, we found that providing dietary advice to patients with IBS in the clinical setting reduces GI symptoms, but without obvious differences between a low-FODMAP diet and traditional IBS dietary advice. The assessment of food diaries demonstrated that it seems possible to give dietary advice and reach the desired effects, for example, reduced intake of FODMAPs, based on careful verbal and written instructions, but that calorie and nutrient intakes need to be monitored thoroughly in
Acknowledgments
Author contributions: LB: study concept and design; dietary advice; acquisition of data; analysis and interpretation of data; drafting of manuscript; statistical analysis. SS: study concept and design; supervision of dietitians; critical revision of the manuscript for important intellectual content. TL: dietary advice; acquisition of data; critical revision of the manuscript for important intellectual content. LC: dietary advice; acquisition of data; critical revision of the manuscript for
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Conflicts of interest The authors disclose no conflicts.
Funding This work was supported by the Swedish Medical Research Council (grants 13409, 21691 and 21692); the Marianne and Marcus Wallenberg Foundation, University of Gothenburg; Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of Gothenburg; and the Faculty of Medicine, University of Gothenburg.
Author names in bold designate shared co-first authorship.