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Semin Thromb Hemost 2012; 38(05): 463-468
DOI: 10.1055/s-0032-1305781
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Helicobacter Pylori-Associated Idiopathic Thrombocytopenic Purpura: A Narrative Review

Massimo Franchini
1   Dipartimento di Medicina Trasfusionale ed Ematologia, Azienda Ospedaliera C. Poma, Mantova, Italy
,
Pier Paolo Vescovi
2   Divisione di Medicina, Azienda Ospedaliera C. Poma, Mantova, Italy
,
Massimo Garofano
2   Divisione di Medicina, Azienda Ospedaliera C. Poma, Mantova, Italy
,
Dino Veneri
3   Dipartimento di Medicina Sperimentale e Clinica, Sezione di Ematologia, Azienda Ospedaliera Universitaria Integrata di Verona, Italy
› Author Affiliations
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Publication History

Publication Date:
06 March 2012 (online)

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Abstract

The Gram-negative bacterium Helicobacter pylori has a well-demonstrated role in several gastroduodenal diseases, including peptic ulcer disease, chronic active gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma. In addition, more recently, several studies have focused on the possible causal role of H. pylori in various extragastric disorders, such as cardiovascular, respiratory, neurological, skin, and autoimmune conditions. The current status of the research on the pathogenesis, clinical and therapeutic aspects of H. pylori-associated idiopathic thrombocytopenic purpura in adults and children will be addressed in this narrative review.

Keywords

Helicobacter pylori - thrombocytopenia - bleeding - eradication therapy
 

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