Thromb Haemost 1995; 74(04): 1185-1190
DOI: 10.1055/s-0038-1649901
Scientific And Standardization Committee Communications
Schattauer GmbH Stuttgart

Criteria for the Diagnosis of Lupus Anticoagulants: An Update

On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH
John T Brandt
The Dep. of Pathology, Ohio State University, Columbus, Ohio, USA
1   Dep. of Pathology, Ball Memorial Hospital, Muncle, Indiana, USA
2   Dep. of Hematology, Walter Reed Army Research Institute, Washington, D. C., USA,
3   Dep. of Internal Medicine, University Hospital, Frankfurt/Maln, Germany
,
Douglas A Triplett
The Dep. of Pathology, Ohio State University, Columbus, Ohio, USA
1   Dep. of Pathology, Ball Memorial Hospital, Muncle, Indiana, USA
,
Barbara Alving
The Dep. of Pathology, Ohio State University, Columbus, Ohio, USA
2   Dep. of Hematology, Walter Reed Army Research Institute, Washington, D. C., USA,
,
Inge Scharrer
The Dep. of Pathology, Ohio State University, Columbus, Ohio, USA
3   Dep. of Internal Medicine, University Hospital, Frankfurt/Maln, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Exner T, Triplett DA, Taberner D, Machin SJ. Guidelines for testing and revised criteria for lupus anticoagulants. Thromb Haemost 1991; 65: 320-325
  • 2 Sletnes KE, Gravem K, Wisloff F. Preparation of plasma for the detection of lupus anticoagulants and antiphospholipid antibodies. Thromb Res 1992; 66: 43-53
  • 3 Kaczor DA, Bickford NN, Triplett DA. Evaluation of different mixing study reagents and dilution effect in lupus anticoagulant testing. Am J Clin Pathol 1991; 95: 408-411
  • 4 Brien WF, Schaus MR, Cooper KE, O’Keefe BT, Inwood M. Lupus anticoagulant testing: effect of the platelet count on the activated partial thromboplastin time. Br J Biomed Sci 1993; 50: 114-116
  • 5 Lupus Anticoagulant Working Party. Guidelines on testing for the lupus anticoagulant J Clin Pathol 1991; 44: 885-889
  • 6 Haemostasis Committee of the ”Socićtc Française De Biologie Clinique”. Laboratory heterogeneity of the lupus anticoagulant: a multicentre study using different clotting assays on a panel of 78 samples Thromb Res 1992; 66: 349-364
  • 7 Arnout J, Vanrusselt M, Huybrechts E, Vermylen J. Optimization of the dilute prothrombin time for the detection of the lupus anticoagulant by use of a recombinant tissue factor. Br J Haematol 1994; 87: 94-99
  • 8 Working Group on Haemostasis of the ”Sociéte Française De Biologie Clinique”. Comparison of a standardized procedure with current laboratory practices for the detection of lupus anticoagulant in France Thromb Haemost 1993; 70: 781-786
  • 9 Schjetlein R, Wisloff F. An evaluation of two commercial test procedures for the detection of lupus anticoagulant. Am J Clin Pathol 1995; 103: 108-111
  • 10 Berard M, Boffa M-C, Karmochkine M, Aillaud M-F, Juhan-Vague I, Frances C, Cacoub P, Piette J-C, Harle J-H. Plasma reactivity to hexagonal II phase phosphatidylethanolamine is more frequently associated with lupus anticoagulant than with antiphosphatidylethanolamine antibodies. J Lab Clin Med 1993; 122: 601-605
  • 11 Feng C-S, Tsang SS F, Li EK. Evaluation of laboratory tests for lupus anticoagulant in a group of Chinese lupus patients. Pathology 1994; 26: 40-42
  • 12 Forastiero RR, Cerrato GS, Carreras LO. Evaluation of recently described tests for detection of the lupus anticoagulant. Thromb Haemost 1994; 72: 728-733
  • 13 Johns AS, Chamley L, Ockelford PA, Pattison NS, McKay EJ, Corkill M. Hart H: Comparison of tests for the lupus anticoagulant and antiphospholipid antibodies in systemic lupus erythematosus. Clin Exper Rheumatol 1994; 12: 523-526
  • 14 Blanco AN, Grand BE, Pieroni G, Penalva LB, Voto LS, Lazzari MA. Behavior of diluted activated partial thromboplastin time in pregnant women with a lupus anticoagulant. Am J Clin Pathol 1993; 100: 99-102
  • 15 Robert A. Two different incubation times for the activated partial thromboplastin time (APTT): a new criterion for diagnosis of lupus anticoagulant. Thromb Haemost 1994; 71: 220-224
  • 16 O’Neill AI, Abrahim KM A, Parkin JD. Automation of the kaolin clotting time. Pathology 1992; 24: 12-14
  • 17 Exner T, Rickard KA, Kronenberg H. A sensitive test demonstrating lupus anticoagulant and its behavioural patterns. Br J Haematol 1978; 40: 143-151
  • 18 Jouhikainen T, Julkunen H, Vaarala O, Leirisalo-Repo M, Stephansson E, Vahtera E, Palosuo T, Myllyla G. Antiphospholipid antibodies and thrombosis in systemic lupus erythematosus: comparison of three lupus anticoagulant assays and anticardiolipin ELISA in 188 patients. Blood Coag Fibrinol 1992; 3: 407-414
  • 19 Clyne LP, Yen Y, Kriz NS, Breitenstein MG. The lupus anticoagulant: high incidence of ’negative’ mixing studies in a human immunodeficiency virus-positive population. Arch Pathol Lab Med 1993; 117: 595-601
  • 20 Triplett DA, Brandt JT, Maas RL. The laboratory heterogeneity of lupus anticoagulants. Arch Pathol Lab Med 1985; 109: 946-951
  • 21 Clyne LP, White PF. Time dependency of lupuslike anticoagulants. Arch Int Med 1988; 148: 1060-1063
  • 22 Rosner E, Pauzner R, Lusky A, Modan M, Many A. Detection and quantitative evaluation of lupus circulating anticoagulant activity. Thromb Haemost 1987; 57: 144-147
  • 23 Arnout J, Huybrechts E, Vanrusselt M, Vermylen J. A new lupus anticoagulant neutralization test based on platelet-derived vesicles. Br J Haematol 1992; 80: 341-346
  • 24 Saxena R, Saraya AK, Kotte VK, Singh YN, Prasad L, Malviya AN. Inosithin neutralization test to measure lupus anticoagulants. Am J Clin Pathol 1993; 99: 61-64
  • 25 Chantarangkul V, Tripodi A, Arbini A, Mannucci PM. Silica clotting time (SCT) as a screening and confirmatory test for detection of the lupus anticoagulants. Thromb Res 1992; 67: 355-365
  • 26 Liu HW, Wong KL, Lin CK, Wong WS, Tse PW T, Chan GT C. The reappraisal of dilute thromboplastin inhibition test in the diagnosis of lupus anticoagulants. Br J Haematol 1989; 72: 229-234
  • 27 Stevenson KJ, Sneddon JM. The role of lipids in the detection of lupus anticoagulant by the dilute Russell viper venom test: are platelets or reagents containing hexagonal HII phases necessary. Br J Haematol 1994; 86: 583-589
  • 28 Triplett DA, Stocker KF, Unger GA, Barna LK. The Textarin/Ecarin ratio: a confirmatory test for lupus anticoagulants. Thromb Haemost 1993; 70: 925-932
  • 29 Rooney AM, McNally T, Mackie IJ, Machin SJ. The Taipan snake venom time: a new test for lupus anticoagulant. J Clin Pathol 1994; 47: 497-501
  • 30 Triplett DA, Barna LK, Unger GA. A hexagonal(II) phase phospholipid neutralization assay for lupus anticoagulant identification. Thromb Haemost 1993; 70: 787-793
  • 31 Reber G, Roisin J-P, Migaud M, deMoerloose P. Comparison of a platelet neutralization procedure with a hexagonal phase phospholipid neutralization assay as confirmatory tests for the presence of lupus anticoagulants. Thromb Res 1994; 73: 131-135
  • 32 Exner T, Papadopulos G, Koutts J. Use of a simplified dilute Russell’s viper venom time(DRVVT) confirms heterogeneity among ’lupus anticoagulants’. Blood Coag Fibrinol 1990; 1: 259-266
  • 33 Exner T. Some recent developments with lupus anticoagulants. Blood Coag Fibrinol 1994; 5: 281-289
  • 34 Schjetlein R, Sletnes KE, Wisloff F. A quantitative, semi-automated and computer assisted test for lupus anticoagulants. Thromb Res 1993; 69: 239-250
  • 35 Brandt JT, Triplett DA, Rock WA, Bovill EG, Arkin CF. Effect of lupus anticoagulants on the activated partial thromboplastin time. Arch Pathol Lab Med 1991; 115: 109-114
  • 36 Clyne LP, Honig CL, Dainiak N. Correction of clotting factor ”deficiencies” in plasma from patients with lupus-like anticoagulants. Thromb Haemost 1984; 51: 317-320
  • 37 Clyne LP. Species specificity of lupus-like anticoagulants. Blut 1986; 53: 287-292
  • 38 Bajaj SP, Rapaport SI, Fierer DS, Herbst KD, Schwartz DB. A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome. Blood 1983; 61: 684-692
  • 39 Edson JR, Vogt JM, Hasegawa DK. Abnormal prothrombin crossed-immuno-electrophoresis in patients with lupus inhibitors. Blood 1984; 64: 807-816
  • 40 Bernini JC, Buchanan GR, Ashcraft J. Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant. J Pediatr 1993; 123: 937-939
  • 41 Permpikul P, Rao LV M, Rapaport SI. Functional and binding studies of the roles of prothrombin and (β2-glycoprotein I in the expression of lupus anticoagulant activity. Blood 1994; 83: 2878-2892