Chest
Clinical Investigations: Interstitial Lung DiseaseDesquamative Interstitial Pneumonia and Respiratory Bronchiolitis-Associated Interstitial Lung Disease
Section snippets
Materials and Methods
We conducted a computer-assisted search of the Mayo Clinic database to identify cases of DIP and RB-ILD that were seen at our institution over a 12-year period between January 1, 1990, and December 31, 2001. All lung biopsy specimens were reviewed to confirm the histopathologic pattern of either DIP or RB-ILD.
RB-ILD was defined by the presence of clinical and radiologic evidence of ILD occurring in a patient with histologically proven respiratory bronchiolitis (RB) seen on a surgical lung
Results
We identified 23 patients with DIP and 12 patients with RB-ILD who were seen at our institution over a 12-year period between 1990 and 2001. The mean (± SD) duration of follow-up from the initial visit at our medical center with diagnosis was 19.6 ± 29.5 and 11.8 ± 16.5 months, respectively, for subjects with DIP and RB-ILD. The mean duration of follow-up from the time of surgical biopsy was 37.7 ± 44.6 and 17.3 ± 15.4 months, respectively, for subjects with DIP and RB-ILD. Bronchoscopy with
Discussion
DIP and RB-ILD are relatively uncommon forms of ILD that are strongly associated with cigarette smoking. Our study confirms the preponderance of smokers among subjects diagnosed with either DIP or RB-ILD. Others have demonstrated a history of smoking in about 90% of patients.1314 In never-smokers, DIP is occasionally observed to be associated with other conditions, including connective tissue diseases and drug-induced lung disease.9 A lesion resembling DIP has been described14 in infants with
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This research was supported by Mayo Institutional funds and the Robert N. Brewer Family Foundation.
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