Chest
Original Research: Interstitial Lung DiseaseTransbronchial Biopsy in Usual Interstitial Pneumonia
Section snippets
Materials and Methods
Written informed consent was obtained from each patient or guardian. The protocol was approved by the local Institutional Review Board or Ethics Committee at each institution, and was in accordance with the recommendations found in the Helsinki Declaration of 1975.
Twenty-two patients with UIP who underwent TBB were identified. In 21 patients, the diagnosis was confirmed by SLB and/or explant specimens (19 by SLB, 2 by explant specimens). The histologic diagnosis of UIP was based on accepted
Clinical Features
There were 9 men and 13 women (age range, 31 to 83 years; mean, 51 years). All patients had dyspnea at presentation, and it had been present from 1 to 60 months (mean, 16 months) in 19 patients in whom this information was known. One patient (case 9) was discovered incidentally during a testicular cancer workup to have interstitial lung infiltrates on chest radiographs, and then retrospectively noted that shortness of breath had been present for 6 months. Two patients (cases 11 and 20) had a
Discussion
Our findings suggest that TBB may be more useful than previously recognized in confirming UIP. The fact that 7 of our 22 cases showed changes considered diagnostic of UIP and an additional 2 cases were considered consistent with UIP indicates that significant changes can be recognized even in these small samples. It should be remembered, however, that all patients had clinical and radiographic features compatible with UIP, including chronic dyspnea, restrictive pulmonary function, interstitial
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
This work was funded by NIH-NHLBI P50 HL67665.