Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials

J Clin Oncol. 2004 Dec 15;22(24):5022-5. doi: 10.1200/JCO.2004.04.272.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Acetaldehyde / adverse effects*
  • Acetaldehyde / analogs & derivatives*
  • Acetaldehyde / chemistry
  • Aged
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / chemistry
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Brain Diseases / chemically induced*
  • Carcinoma / drug therapy
  • Chemistry, Pharmaceutical
  • Esophageal Neoplasms / drug therapy
  • Excipients / adverse effects*
  • Fatal Outcome
  • Female
  • Fluorouracil / adverse effects*
  • Fluorouracil / chemistry
  • Fluorouracil / therapeutic use*
  • Humans
  • Hyperammonemia / chemically induced*
  • Male
  • Malonates / adverse effects*
  • Middle Aged
  • Rectal Neoplasms / drug therapy
  • Tromethamine / adverse effects*
  • Ventricular Dysfunction, Left / chemically induced*

Substances

  • Antimetabolites, Antineoplastic
  • Excipients
  • Malonates
  • fluoromalonic acid semialdehyde
  • Tromethamine
  • fluoroacetaldehyde
  • Acetaldehyde
  • Fluorouracil