Patients who have had an organ transplant have a need for highly effective contraception. Intrauterine devices, depo-medroxyprogesterone acetate, and implantable etonorgestrel have the highest efficacy combined with the least chance of interaction with antirejection medication regimens. Combined hormonal contraceptives and progestin-only pills are also acceptable methods for patients who do not have other contraindications to their use. Barrier method use should be advocated for any patient who is entering a new sexual relationship and as an adjunct to other methods. Consultation with a gynecologist experienced with the provision of contraceptives to medically complicated patients is advised for all women of reproductive age who have received an organ transplant.