Atypical femoral fractures, bisphosphonates, and adult hypophosphatasia

J Bone Miner Res. 2009 Jun;24(6):1132-4. doi: 10.1359/jbmr.081253.

Abstract

Lateral subtrochanteric femoral pseudofractures occurring in adults with osteomalacia from hypophosphatasia and X-linked hypophosphatemia support the hypothesis that atypical femoral fractures in osteoporosis treated with bisphosphonates also result from low bone turnover.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diphosphonates / therapeutic use*
  • Familial Hypophosphatemic Rickets / complications*
  • Femoral Fractures / complications*
  • Femoral Fractures / prevention & control*
  • Genetic Diseases, X-Linked*
  • Humans

Substances

  • Diphosphonates