Abstract
Urticarial vasculitis is characterized clinically by urticaria-like skin lesions and histologically by leukocytoclastic vasculitis. It may be idiopathic or associated with various conditions such as infections, hematologic disorders, drugs, and connective tissue diseases, primarily systemic lupus erythematosus; an association with mixed connective tissue disease (MCTD) has rarely been reported. We present a case of hypocomplementemic urticarial vasculitis in a patient with MCTD that responded to hydroxychloroquine after a period of corticosteroid dependence.
MeSH terms
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Complement C3c / deficiency
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Complement C4 / deficiency
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Female
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Humans
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Hydroxychloroquine / therapeutic use
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Middle Aged
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Mixed Connective Tissue Disease / complications*
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Mixed Connective Tissue Disease / drug therapy
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Mixed Connective Tissue Disease / immunology
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Prednisone / therapeutic use
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Raynaud Disease / etiology
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Urticaria / drug therapy
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Urticaria / etiology*
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Urticaria / immunology
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Vasculitis, Leukocytoclastic, Cutaneous / drug therapy
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Vasculitis, Leukocytoclastic, Cutaneous / etiology*
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Vasculitis, Leukocytoclastic, Cutaneous / immunology
Substances
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Complement C4
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Hydroxychloroquine
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Complement C3c
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Prednisone