Abstract
Human rickettsioses caused by intracellular bacteria of the genus Rickettsia are distributed worldwide and are transmitted by arthropod vectors such as ticks, fleas, mites and lice. They have a wide range of manifestations from benign to life-threatening diseases. Mortality rates of up to 30% have been reported for some rickettsioses. Here, the authors will review in vitro and human studies of the various compounds that have been used for the treatment of Rickettsia spp. infections. The authors will also provide recommendations for the treatment of spotted fever and typhus group rickettsioses.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use*
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Doxycycline / administration & dosage
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Doxycycline / adverse effects
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Doxycycline / therapeutic use*
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Humans
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MEDLINE
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Rickettsia
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Rickettsia Infections / drug therapy*
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Rickettsia Infections / epidemiology
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Rickettsia Infections / microbiology
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Tick-Borne Diseases / drug therapy*
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Tick-Borne Diseases / epidemiology
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Tick-Borne Diseases / microbiology
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Treatment Outcome
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Typhus, Endemic Flea-Borne / drug therapy
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Typhus, Endemic Flea-Borne / epidemiology
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Typhus, Endemic Flea-Borne / microbiology
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Typhus, Epidemic Louse-Borne / drug therapy
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Typhus, Epidemic Louse-Borne / epidemiology
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Typhus, Epidemic Louse-Borne / microbiology
Substances
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Anti-Bacterial Agents
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Doxycycline