Abstract
Paget's disease of the breast is a disorder of the nipple-areola complex that, while rare, is often associated with an underlying carcinoma. It is characterized by eczematoid changes of the nipple. Two theories have been proposed to explain the pathogenesis of Paget's disease. The Epidermotropic, which is the most accepted theory, suggests that Paget's cells originate from ductal cancer cells that had migrated from the underlying breast parenchyma. It is supported by the predominance of breast cancer markers found in Paget's disease. This article provides an overview of Paget's disease of the breast with special attention to immunohistochemistry and raises the question of new therapeutic approaches.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis
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Breast Neoplasms / chemistry
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Breast Neoplasms / diagnosis
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Breast Neoplasms / etiology
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Breast Neoplasms / pathology*
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Breast Neoplasms / therapy
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Breast Neoplasms, Male / chemistry
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Breast Neoplasms, Male / diagnosis
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Breast Neoplasms, Male / etiology
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Breast Neoplasms, Male / pathology
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Breast Neoplasms, Male / therapy
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Cell Movement
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Cell Transformation, Neoplastic
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Combined Modality Therapy
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Diagnosis, Differential
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Diagnostic Imaging / methods
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Epidermis / pathology
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Female
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Humans
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Keratinocytes / pathology
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Male
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Mastectomy / methods
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Middle Aged
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Neoplasm Proteins / analysis
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Nipples / pathology
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Paget Disease, Extramammary / pathology
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Paget's Disease, Mammary / chemistry
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Paget's Disease, Mammary / diagnosis
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Paget's Disease, Mammary / etiology
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Paget's Disease, Mammary / pathology*
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Paget's Disease, Mammary / therapy
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Prognosis
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Young Adult
Substances
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Biomarkers, Tumor
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Neoplasm Proteins