Antibodies to phosphatidylserine/prothrombin complex and the antiphospholipid syndrome

Lupus. 2014 Oct;23(12):1309-12. doi: 10.1177/0961203314538332.

Abstract

Antibodies to prothrombin can be detected by ELISA using prothrombin coated onto irradiated plates (aPT) or the phosphatidylserine/prothrombin complex as antigen (aPS/PT) and they have been both related with the clinical manifestation of APS. Current evidence supports the concept that they belong to distinct populations of autoantibodies. Nevertheless, they can both be detected simultaneously in one patient. This mini-review will focus on data available on aPS/PT antibodies and their clinical utility in the diagnosis of APS.

Keywords: Antiphospholipid antibodies; anti-phosphatidylserine; antiphospholipid syndrome; antiprothrombin; stroke; thrombosis; venous thrombosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiphospholipid Syndrome / diagnosis*
  • Autoantibodies / blood*
  • Humans
  • Lupus Coagulation Inhibitor / blood
  • Phosphatidylserines / immunology*
  • Prothrombin / immunology*
  • Risk Factors
  • Thrombosis / etiology

Substances

  • Autoantibodies
  • Lupus Coagulation Inhibitor
  • Phosphatidylserines
  • Prothrombin